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Coliprotec® Vaccine Toolkit

Coliprotec® F4/F18 is a live oral vaccine which can be used in piglets from 18 days of age to protect them against Post-weaning Diarrhoea (PWD) due to F4-F18 ETEC.

Coliprotec® F4/F18 delivers healthy piglets with 1Kg or more at the end of nursery, which may result in 2 Kg of additional slaughter weight1. Coliprotec® F4/F18 vaccinated animals can reach market weight up to 7 days sooner, with a substantial reduction in nursery medication use2.

This hub aims to provide a resource for the use of the Coliprotec vaccine. Resources include application guides, educational materials, tools and content for producers, vets & nutritionists that all have a common interest in the intestinal health of young pigs.

Practical Guide to Oral Vaccination


Learn how to vaccinate your piglets using the Coliprotec® F4/F18 vaccine, from start to finish. Presented by Frédéric Vangroenweghe. Webinar/Video (10.20).




<h2 style="margin-top:5%">Vaccination in Drinking Water Guide (pdf)</h2> A step by step administration guide for before and after weaning.<br><a href="https://assets-eu-01.kc-usercontent.com/7d1fb288-b93d-015d-f61e-abc4dbdfe522/bf8aff21-cca3-48bc-8139-ad14dfe88255/Protec_Vaccination_in_Drinking_Water_Guide__1_.pdf" target="_blank"><img src="https://assets-eu-01.kc-usercontent.com/7d1fb288-b93d-015d-f61e-abc4dbdfe522/39898d67-c89e-42db-a546-76ac5d564032/drinking-water.jpg" alt="drinking-water" width="650" /></a> <h2 style="margin-top:5%">Coliprotec Application Guidelines with Milk</h2> Step-by-step guidelines of how to apply Coliprotec through water bowls before weaning,<br>with milk.<br><a href="https://assets-eu-01.kc-usercontent.com/7d1fb288-b93d-015d-f61e-abc4dbdfe522/bbf21372-6eb1-434d-aeba-fe2bb27c41ca/Approved_-_MILK_COLIPROTEC_Worksheet_Application_Through_Water_Bowl_Milk_210420.pdf" target="_blank"><img src="https://assets-eu-01.kc-usercontent.com/7d1fb288-b93d-015d-f61e-abc4dbdfe522/e2f01663-7307-4ff2-910d-f6abf85d50b0/coliprotec-milk.jpg" alt="drinking-water" width="650" /></a> <h2 style="margin-top:5%;width:600px">Coliprotec Application Guidelines with Electrolytes (pdf)</h2> Step-by-step guidelines of how to apply Coliprotec through water bowls before weaning,<br>with electrolytes.<br><a href="https://assets-eu-01.kc-usercontent.com/7d1fb288-b93d-015d-f61e-abc4dbdfe522/bbf21372-6eb1-434d-aeba-fe2bb27c41ca/Approved_-_MILK_COLIPROTEC_Worksheet_Application_Through_Water_Bowl_Milk_210420.pdf" target="_blank"><img src="https://assets-eu-01.kc-usercontent.com/7d1fb288-b93d-015d-f61e-abc4dbdfe522/56aab94b-b15b-4a45-aa6d-ec219ecad00c/electrolytes.jpg" alt="electrolytes" width="650" /></a> <p><p><br> References 1. Purina report- “Each production phase impacts the next”. Retrieved from: https://www.purinamills.com/purinamills/media/PDF/Swine/Progress-to-Profit/Purina-Each-Production-Phase-Impacts-the-Next-3_16.pdf. 2. Vangroenweghe, F. et al., 2018. Proceedings of the 10th ESPHM, p. 252.<p> PM-UK-20-0430 <br> Pig World References <br> *E. coli*-related refers to F4/F18 enterotoxigenic *E. coli* strains 1. Vangroenweghe, Frédéric. Improved weight gain and reduced mortality and antibiotic use following vaccination with Coliprotec® F4, an oral live vaccine against post-weaning diarrhoea. 2017. Proceedings ESPHM, Prague, Czech Republic: 254. Coliprotec® F4/F18 is an oral vaccine used for active immunization of pigs from 18 days of age against enterotoxigenic F4-positive and F18-positive *Escherichia coli* in order to reduce the incidence of moderate to severe post-weaning diarrhoea infected pigs and reduce the faecal shedding of enterotoxigenic F4-positive and F18-positive *E. coli* from infected pigs. Each dose of vaccine contains 1.3 x 10<sup>8</sup> to 9.0 x 10<sup>8</sup> CFU of live non-pathogenic *Escherichia coli* O8:K87 (F4ac) and 2.8 x 10<sup>8</sup> to 3.0 x 10<sup>9</sup> CFU of live non-pathogenic *Escherichia coli* O141:K94 (F18ac). Refer to the product packaging and leaflets for information about side effects, precautions, warnings and contraindications. Legal category POM-V. Elanco UK AH Limited, First Floor, Form 2, Bartley Wood, Bartley Wood Business Park, Hook RG27 9XA. Telephone: 01256 353131 Email: elancouk@elanco.com. Coliprotec® is a registered trademark of Prevtec Microbia Inc., used under license by Elanco or its affiliates. Elanco and the diagonal bar are trademarks of Elanco or its affiliates. ©2021 Elanco or its affiliates. Use medicines responsibly www.noah.co.uk/responsible. PM-UK-21-0356

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