Hemicell XT frequently asked questions

What are the technical specifications of Hemicell XT?

- Patented feed enzyme = Endo-1,4-β-mannanase
- Produced by Paenibacillus lentus
- Heat tolerance to pelleting temperatures of 190⁰ F/88⁰ C
- Approved for use in poultry (broilers and turkeys) and swine diets in most major markets

What is the guaranteed analysis of Hemicell XT?

Hemicell XT has guaranteed potency to ensure sufficient β-Mannanase activity in the final feed to prevent a feed induced immune response (FIIR):

- Hemicell XT (dry) β-Mannanase (EC (from Paenibacillus lentus), not less than 360 MU/kg.

How much substrate does Hemicell XT need to be effective?

Use of Hemicell XT to reduce unnecessary immune activity from β-mannans is expected to be cost effective in diets with at least 0.2% soluble β-mannans. The value of Hemicell XT increases in diets with increasing β-mannan content.1,2

Can Hemicell XT be added when other enzymes, vet products or other feed additives are already present in the feed?

Yes. Hemicell XT is safe to use with other products. The only known contraindications for Hemicell XT are with formaldehyde based products, which may denature Hemicell XT (and other enzymes) when they are added to the feed at the same time.3 The specific mode of action of Hemicell XT has not been shown to interact with other enzymes mode of action and many trials have shown that the benefits from Hemicell are additive to the benefits of other enzymes products.4-6

What differentiates Hemicell XT from cocktail enzymes with β-mannanase on the label?

Hemicell XT is a patented enzyme product with a guaranteed minimum β-mannanase activity. This ensures sufficient β-mannanase activity in the final feed to prevent a feed induced immune response (FIIR) from β-mannans, when used as recommended. When evaluating a cocktail enzyme product, you should only consider enzyme activities with a minimum guaranteed potency.


1. Anderson, D.M. & Hsiao H.-Y. 2009. New Feed Enzyme Development. ChemGen Corp. 2009. 1: 1-30

2. Duncan, C., Pugh, N., Pasco, D. and Ross, S. 2002. “Isolation of Galactomannan That Enhances Macrophage Activation from the Edible Fungus Morchella esculenta.” J. Agric. Food Chem. 50: 5683-5685.

3. Sutherland B.W., Toews J., and Kast J. 2008. “Utility of Formaldehyde Cross-Linking and Mass Spectrometry in the Study of Protein–Protein Interactions.” J. Mass Spectrometry. 2008; 43:699–715

4. Knox, A. 2007. “Roslin-ChemGen Broiler Trial 2007: To Evaluate the Efficacy of Hemicell-L in Broilers Fed Reduced Energy Pelleted Diets Based on Wheat – With Xylanase – and Soybean Meal.” Roslin Nutrition Ltd., Scotland.

1 5. Knox, A. 2009. “Roslin-ChemGen Broiler Trial 2009: To Evaluate the Efficacy of Hemicell-L and Hemicell-Ht in Broilers Fed on Pelleted Diets Based on Wheat And Soybean Meal.” Roslin Nutrition Ltd., Scotland.

6. van Eerden, E., et al, 2014. “Effect of Hemicell on Production Performance and Clinical Scores in Broiler Chickens.” Report no. 1366.