What are the technical specifications of Hemicell HT?

- Patented feed enzyme = Endo-1,4-β-mannanase
- Produced by Paenibacillus lentus
- Heat tolerance to pelleting temperatures of 190⁰ F/88⁰ C
- Approved for use in poultry (broilers and turkeys) and swine diets in most major markets

What is the guaranteed analysis of Hemicell HT?

Hemicell HT has guaranteed potency to ensure sufficient β-Mannanase activity in the final feed to prevent a feed induced immune response (FIIR):

- Hemicell HT** (dry) β-Mannanase (EC 3.2.1.78) (from Paenibacillus lentus), not less than 72.5 MU/lb.
- Hemicell HT** (liquid) β-Mannanase (EC 3.2.1.78) (from Paenibacillus lentus), not less than 590 MU/L.

How much substrate does Hemicell HT need to be effective?


Use of Hemicell HT to reduce unnecessary immune activity from β-mannans is expected to be cost effective in diets with at least 0.2% soluble β-mannans. The value of Hemicell HT increases in diets with increasing β-mannan content.1,2

Can Hemicell HT be added when other enzymes, vet products or other feed additives are already present in the feed?

Yes. Hemicell HT is safe to use with other products. The only known contraindications for Hemicell HT are with formaldehyde based products, which may denature Hemicell HT (and other enzymes) when they are added to the feed at the same time.3 The specific mode of action of Hemicell HT has not been shown to interact with other enzymes mode of action and many trials have shown that the benefits from Hemicell are additive to the benefits of other enzymes products.4-6

What differentiates Hemicell HT from cocktail enzymes with β-mannanase on the label?


Hemicell HT is a patented enzyme product with a guaranteed minimum β-mannanase activity. This ensures sufficient β-mannanase activity in the final feed to prevent a feed induced immune response (FIIR) from β-mannans, when used as recommended. When evaluating a cocktail enzyme product, you should only consider enzyme activities with a minimum guaranteed potency.


References:

1. Anderson, D.M. & Hsiao H.-Y. 2009. New Feed Enzyme Development. ChemGen Corp. 2009. 1: 1-30

2. Duncan, C., Pugh, N., Pasco, D. and Ross, S. 2002. “Isolation of Galactomannan That Enhances Macrophage Activation from the Edible Fungus Morchella esculenta.” J. Agric. Food Chem. 50: 5683-5685.

3. Sutherland B.W., Toews J., and Kast J. 2008. “Utility of Formaldehyde Cross-Linking and Mass Spectrometry in the Study of Protein–Protein Interactions.” J. Mass Spectrometry. 2008; 43:699–715

4. Knox, A. 2007. “Roslin-ChemGen Broiler Trial 2007: To Evaluate the Efficacy of Hemicell-L in Broilers Fed Reduced Energy Pelleted Diets Based on Wheat – With Xylanase – and Soybean Meal.” Roslin Nutrition Ltd., Scotland.

1 5. Knox, A. 2009. “Roslin-ChemGen Broiler Trial 2009: To Evaluate the Efficacy of Hemicell-L and Hemicell-Ht in Broilers Fed on Pelleted Diets Based on Wheat And Soybean Meal.” Roslin Nutrition Ltd., Scotland.

6. van Eerden, E., et al, 2014. “Effect of Hemicell on Production Performance and Clinical Scores in Broiler Chickens.” Report no. 1366.